Dexamethasone

Dexamethasone

CAS No.: 50-02-2

  Other Names: DXM

  MF: C22H29FO5

  EINECS No.: 200-003-9

Product Details

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Dexamethasone is a potent synthetic member of the glucocorticoidclass of steroid drugs. It acts as an anti-inflammatory and immunosuppressant.

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Items

Specifications

Results

Appearance

Almost white crystal or crystalline powder 

White powder, 

Identification

The retention time of the major peak 

in the chromatogram of the 

Assay prepration corresponds to that in

the chromatogram of the standard preparation,

as obtained in the assay

 

Complies

Specific rotation

Between -28.6°and -35.0°, measured at 20°

-32.8°

Water

not more than 0.5%

0.12%

residue on ignition

not more than 0.2%

0.11%

Heavy metals

not more than 0.001%

complies

related compounds by HPLC(Test1)

Fructose not more than 0.3% Compound 

A not more than 0.3% Other individual impurity not more than 0.1% 

Total impurities not more than 0.5% 

Fructose: 0.03% Compound A: 0.04% 

Total impurities: 0.07%

Particle size

90% less than 350 microns

complies

Limit of sulfamate and sulfate

Sulfamate ion not more than 0.10% 

Sulfate ion not more than 0.10%

complies

Residual Solvent

Methylene Chloride not more than 250μg/g

Acetone not mor than 2500μg/g

Isopropanol not more than 5000μg/g

Ethanenitrile not more than 400μg/g

n-hexane not more than 290μg/g

Ethyl Acetate not more than 2500μg/g

Pyridine not more than 100μg/g

not detected

Assay

Topiramate contains not less than 98.0% and 

not more than the equivalent of 102.0% of C12H21NO8S, calculated with reference to the Anhydrous Basis

99.80%

Conclustion

The material complies with respect to USP32


 

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Dexamethasone is an antiinflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). it has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein. it has been observed to induce apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils. that is an activator of IDO.

 

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Dexamethasone

25kg/Fiber Drum (35 cm* 53 cm), Double plastic bag inside;

1Kg/Aluminum foil bag, with single plastic inside, and carton outside;

And other package, or as your requirements.

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Dexamethasone

Delivery: Sea/ Air Shipping & International Express  

Shipping Time: 2-3 working days after payment  

Storage: Kept away from strong light and heat.                                                                                    

Shelf Life: 24 months

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Q1: Are you manufacturer or trading company ?

A:We are trader with ISO22000,Kosher,Halal,HACCP certified over 10 years.

 

Q2:How can we guarantee you receive a good quality Dexamethasone?

A: Our own factory comply to GMP standard and run with strict quality control,every batch of the product must be tested and ensure the quality before shipment.

 

Q3: What’s the delivery and shipping ?

A:For sample,around 1-3days to be sent out upon receipt of payment by

DHL,Fedex,TNT,UPS,EMS or SF.

For small order, please expect 3-7days by DHL. FedEx,TNT,UPS EMS or SF.

For bulk order, around 2 weeks to finish production from order confirmation,will be delivered by air or sea as customer requested.

 

Q4: Can I get some sample to test the quality?

A: Of course you can, a 20g-30g free sample is available for you to test.

 

Q5: What’s the payment?

A: We accept T/T,L/C,D/A,D/P,Western Union,Paypal.

 

Q6:What is your package and storage?

A:25kg per paper drum with double layer poly bag inside.

Store in cool and dry place, keep away from strong light and heat.

 

Q7:What is your return service policy?

A: We offer a 45days guarantee on receipt of goods without any damage to packing. We will return your money if our products don’t conform to your approved quality.

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